https://samnicholls.net/2016/01/21/meet-the-metahaplome/ The Exciting Adventures of Sam Wed, 02 Mar 2016 03:10:42 +0000 hourly 1 https://wordpress.org/?v=5.7.5 https://samnicholls.net/2016/01/21/meet-the-metahaplome/#comment-19 Wed, 02 Mar 2016 01:41:59 +0000 https://samnicholls.net/?p=549#comment-19 […] At the end of January I gave a talk at the Aberystwyth Bioinformatics Workshop. The talk briskly sums up the work done so far over the first year-and-a-bit of my PhD and introduces the metahaplome: our very own new -ome, a graph-inspired representation of the variation in single nucleotide polymorphisms observed across aligned reads from a sequenced metagenome. The idea is to isolate and store information only the genomic positions that actually vary across sequenced reads and more importantly, keep track of the observed evidence for these variations to co-occur together. This evidence can be exploited to reconstruct sequences of variants that are likely to actually exist in nature, as opposed to the crude approximations provided by assembly-algorithm-de-jour. […]

]]>