I got really cross with bioinformatics, so stuck my laptop in a laser cutter. The result was pretty satisfying.
My datasets are so big, they trigger an NFS bug in the kernel
My back of the envelope worst case calculation indicates 2.8 million decillion decillion possible valid paths so in retrospect, yes it was a bad idea to try and enumerate these to a terminal.
Just when I think I have tricked the computer into finally doing what I want, it reveals that it has come up with a new way to fail obscurely and avoid detection.